WebOxaliplatin Related Compound A. HO2CCO2H · 2H2O. Synonyms: Oxalic acid dihydrate, Ethanedioic acid dihydrate. CAS 6153-56-6. Molecular Weight 126.07. Browse Oxaliplatin … WebOxaliplatin: a review of preclinical and clinical studies Of the new generation platinum compounds that have been evaluated, those with the 1,2-diaminocyclohexane carrier ligand-including oxaliplatin--have been focused upon in recent years.
Improving the response to oxaliplatin by targeting chemotherapy …
WebThe available human data do not establish the presence or absence of major birth defects or miscarriage related to the use of oxaliplatin injection. ... oxaliplatin exhibits in vitro and in vivo antiproliferative activity greater than either compound alone in several tumor models (HT29 [colon], GR [mammary], and L1210 [leukemia]). WebOxaliplatin, a third generation platinum compound, may provide less toxicity and be more effective. A phase 2 study was performed to estimate the response rate to single agent oxaliplatin in patients with refractory pediatric solid tumors, and to further describe the toxicities and pharmacokinetics of the drug in this population. Patients and ... mount board sheet near me
[Oxaliplatin Related Compound B (15 mg) ([SP-4-2-(1R …
Oxaliplatin, sold under the brand name Eloxatin among others, is a cancer medication (platinum-based antineoplastic class) used to treat colorectal cancer. It is given by injection into a vein. Common side effects include numbness, feeling tired, nausea, diarrhea, and low blood cell counts. Other serious side effects … See more Oxaliplatin is used for treatment of colorectal cancer, typically along with folinic acid (leucovorin) and fluorouracil in a combination known as FOLFOX or along with capecitabine in a combination known as See more Side-effects of oxaliplatin treatment can potentially include: • Neurotoxicity leading to chemotherapy-induced peripheral neuropathy See more Oxaliplatin was discovered in 1976 at Nagoya City University by Professor Yoshinori Kidani, who was granted U.S. Patent 4,169,846 in … See more • Graham J, Mushin M, Kirkpatrick P (January 2004). "Oxaliplatin" (PDF). Nature Reviews. Drug Discovery. 3 (1): 11–12. doi:10.1038/nrd1287. PMID 14756144. Archived from the original (PDF) on 2004-11-08. Retrieved 2005-07-19. See more The compound features a square planar platinum(II) center. In contrast to other drugs of the platinum-based antineoplastic class of drugs See more Eloxatin was covered by patent numbers 5338874 (expired Apr 07, 2013), 5420319 (expired Aug 08, 2016), 5716988 (expired Aug 07, 2015) and … See more • "Oxaliplatin". Drug Information Portal. U.S. National Library of Medicine. • "Oxaliplatin". National Cancer Institute. 5 October 2006. See more WebApr 4, 2024 · Oxaliplatin is a cytotoxic chemotherapy drug used to treat cancer. It is a type of platinum drug and an alkylating agent. Like other alkylating agents, oxaliplatin works by … WebMar 9, 2015 · Oxaliplatin was successfully introduced for the management of advanced colorectal cancer, the second leading cause of cancer death in Western countries [1,2].This antineoplastic agent differs from previous platinum compounds for the configuration of the amino substituents [3,4] and, characteristically, its major dose-limiting side effect is … mount boards