Npas4 function
Web19 feb. 2024 · NPAS4 is critical for the coordination of metabolism during the stimulation of electrically excitable cells; its loss leads to the defects in cellular … Web27 sep. 2024 · Conditional deletion of Npas4 in the NAc significantly reduced cocaine conditioned place preference and delayed learning of the drug-reinforced action during …
Npas4 function
Did you know?
Web1 jul. 2024 · A key function of NPAS4 in excitatory CA1 pyramidal neurons is to mediate recruitment of somatic inhibition in hippocampal pyramidal neurons in … Web1 mei 2014 · Npas4 functions in a cell type-specific manner according to a circuit-wide homeostatic logic. Our analysis of the activity-induced transcription factor Npas4 revealed that this factor is induced in both excitatory and inhibitory neurons and that it functions in SST neurons to positively regulate the function of excitatory, ...
Web6 nov. 2013 · NPAS4 is a transcription factor and thus to understand how it mediates sensory-dependent changes in inhibitory synapse number we sought to identify NPAS4 target genes and assess their function. Web21 mrt. 2024 · NPAS4 is expressed in endothelial cells, regulates VE-cadherin expression and regulates sprouting angiogenesis. This review summarizes the …
Web23 dec. 2011 · Npas4 expression is selectively induced by neuronal activity and contextual learning. We first characterized the induction of Npas4, together with several other IEGs, … Web4 aug. 2024 · Although Npas4 and Gem are reported independently as ischemia-induced genes (20, 38, 39), the functional relationship between them is unknown. Our results show that Gem is transcriptionally activated by Npas4 , whose expression is induced by excessive Ca 2+ influx into the cytoplasm of neurons after stroke ( Fig. 6 ).
Web17 jun. 2014 · Activity-driven transcription is a key event associated with long-lasting forms of neuronal plasticity. Despite the efforts to investigate the regulatory mechanisms that control this complex process and the important advances in the knowledge of the function of many activity-induced genes in neurons, as well as the specific contribution of activity …
Web17 jan. 2014 · NPAS4 functions to maintain excitatory/inhibitory balance in neurons, while mouse models have shown it to play roles in memory formation, social … my keyboards commands not working on autocadWebNPAS4 (bHLHe79, Le-PAS, NXF, PASD10) protein expression summary. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. ... Plays a key role in the structural and functional plasticity of neurons (By similarity). old fashioned letter sealWeb8 mei 2014 · The function of Npas4 in the context of neurodevelopment was investigated using loss-of-function experiments in vitro. We created several mouse ESC lines in which Npas4 expression was reduced during neural differentiation through RNA interference and we then analyzed the ability of these Npas4 knockdown mouse ESCs lines to undergo … my keyboard randomly stops working windows 10Web1 okt. 2024 · Thus, NPAS4 differentially communicates increases in a neuron’s spiking output and synaptic inputs to the nucleus, enabling gene regulation to be tailored to the type of depolarizing activity along the somato-dendritic axis … my keyboard scroll lock key isn\\u0027t workingWebNeuronal PER-ARNT-SIM (PAS) domain protein 4 (NPAS4) is a protective transcriptional regulator whose dysfunction has been linked to a variety of neuropsychiatric and metabolic diseases. As a member... Neuronal PER-ARNT-SIM (PAS) domain protein 4 (NPAS4) is a protective transcriptional old fashioned lite briteWebMaria Filip, MD, PhD in medical science is a board certified psychiatrist working at the Department of Adult Psychiatry Medical University of Lodz as an assistant professor in the years 2024 - 2024. She was awarded with the Walczak NAWA Scholarship Programme - the Polish National Agency for Academic Exchange and spent 3 months of Postdoctoral … my keyboard separated my ipadWebThe neuronal pas domain protein 4 (npas4) is a neuronal activity dependent gene that has recently. been identified as a transcription factor which regulates the transcription of genes that control inhibitory synapse development and synaptic plasticity. The role of npas4 is in learning and memory, however 3D structure of npas4 is unknown . my keyboards caps lock is reversed