2024 Klotho heart

Klotho heart

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WebDec 13, 2016 · We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10 −12). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and … WebCirculation Research is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 doi: 10.1161/01.RES.0000157171.04054.30 ... Association Between a Functional Variant of the KLOTHO Gene and High-Density Lipoprotein Cholesterol, Blood Pressure, Stroke, and Longevity

The role of Klotho and FGF23 in cardiovascular outcomes of …

WebFeb 28, 2024 · Klotho is a known anti-aging protein that also contains anti-inflammatory properties. In a paper published in Nature Scientific Reports, Nakao et al. describe how … pearson mylab purchase

Cardioprotection by Klotho through downregulation of TRPC6 …

WebNational Center for Biotechnology Information WebKlotho levels are known to decline in chronic kidney disease (CKD) and may be an early marker of this disease. Klotho deficiency may be one of the causes for CKD progression … WebAug 8, 2024 · Other klotho variants have been associated with increased/decreased risk of kidney disease and heart disease: Check your genetic data for rs3752472 (23andMe v5 only): C/C: a 2-fold increase in the risk of kidney stones [ ref] C/T: typical risk of kidney stones T/T: typical risk of kidney stones Members: Your genotype for rs3752472 is —. pearson mylab reset student attempt

Association between serum Klotho concentration and heart failure …

Klotho is upregulated in human cardiomyopathy independently of ...

WebKlotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo. Cardiac inflammation and oxidative … WebJan 1, 2024 · A retrospective analysis enrolled 237 chronic heart failure (CHF) patients with ventricular ejection fraction (LVEF) ≤ 45% and found that CHF patients had significantly lower serum Klotho levels than healthy controls [15], but Taneike et al. showed that acute heart failure (AHF) patients with LVEF ≤35% presented an elevated serum Klotho ... meanders in rivers txWebJul 23, 2024 · Klotho is an antiaging protein that modulates oxidative stress, angiogenesis and fibrosis. Here we test the hypothesis that decreased cord Klotho levels in preterm infants predict increased... meanders image

"WebJan 28, 2024 · Recently, it has been identified that soluble Klotho arises exclusively from shedding or proteolytic cleavage. In this review, we will highlight the mechanisms underlying the shedding of Klotho and the functional effects of soluble Klotho, especially in CKD and the associated cardiovascular complications. " - Klotho heart

Klotho heart

Alpha-Klotho is a novel predictor of treatment responsiveness in ...

Web1 day ago · These approaches break down complexity into small and comprehensible challenges. Such holistic computational ecosystems encompass data, methods, processes, and interdisciplinary knowledge to manage the complexity of multiorgan crosstalk. Therefore, this review summarizes the current knowledge of kidney-heart crosstalk, along … WebJan 21, 2024 · Systemically circulating Klotho protects the heart from stress-induced pathological cardiac remodeling and fibrosis 19, 20. Thus, sαKl levels might indicate the status of the heart in...

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WebApr 5, 2012 · Klotho is a 130-kDa transmembrane protein that is predominantly expressed in the distal tubule of the kidney but also in multiple other tissues. 1 The extracellular … WebMar 22, 2024 · Heart disease is the leading cause of death worldwide. The major cause of heart failure is the death of the myocardium caused by myocardial infarction, detrimental cardiac remodeling, and cardiac fibrosis occurring after the injury. This study aimed at discovering the role of the anti-aging protein α-klotho (KL), which is the co-receptor of …

WebFeb 19, 2024 · Conclusions: Klotho deficiency causes cardiac aging via impairing the Nrf2-GR pathway. Supplement of exogenous secreted Klotho represents a promising … WebApr 18, 2024 · The associations among Klotho (exposure), congestive heart failure (CHF; outcome), and renal function markers [estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), uric acid (UA), and urine albumin-to-creatinine ratio (UACR); mediators] were investigated using mediation analysis.

WebDec 27, 2024 · A study in aged mice found that administration of TSG (tetrahydroxystilbene glucose) a constituent of Fo-ti for 8 weeks reversed age related decreases in klotho, increased the levels of klotho in the bloodstream and increased the expression of klotho in the brain, heart, kidney, testis and epididymis in a dose-dependent manner. WebApr 12, 2024 · Tags: F-Klb, FGF21, Heart Disease, Klotho. Previous Post. About the author. Josh Conway Josh is a professional editor and is responsible for editing our articles before they become available to the public as well as moderating our Discord server. He is also a programmer, long-time supporter of anti-aging medicine, and avid player of the strange ...

WebKlotho is an anti-aging protein with pleiotropic actions that exerts organ protection. Several lines of evidence support the notion that Klotho functions as a human aging-suppression molecule. Polymorphisms of KLOTHO are correlated with life span, coronary artery disease, atherosclerosis, and osteoporosis in humans.

WebFeb 20, 2024 · Abstract Klotho protein affects a number of metabolic pathways essential for pathogenesis of cardio-vascular diseases and their prevention. It inhibits lipid peroxidation and inflammation, as well as prevents endothelial injury and calcification of blood vessels. Klotho decreases rigidity of blood vessels and suppresses development of the heart … meanders in the river nileWebJan 1, 2024 · Given the apparent importance of Klotho in oxidative stress and inflammatory responses, and the paucity of systematic investigations into the effects of Klotho on the heart, we explored the potential cardioprotective roles of Klotho in diabetic hearts and in cultured cardiomyocytes incubated with high glucose (HG). meanders in a riverWebApr 15, 2024 · Klotho, a protein that exists in two forms, membrane-bound Klotho and soluble Klotho, and acts as co-receptor for fibroblast growth factor 23 (FGF23), has been … meanders mccallWebKlotho is mainly produced in the kidneys. 6 Its deficiency is associated with the progression of chronic kidney disease and heart disease. Low levels of Klotho in patients with chronic kidney disease can also promote vessel calcification and salt-dependent hypertension. 13 , 14 Animal studies indicate a nephroprotective role of Klotho probably ... meanders migrate or shift their location byWebKlotho deficiency aggravates pathological heart growth. Klotho expression is decreased in aging, a condition associated with increased risk for heart failure 23,24.We examined the role of Klotho in protecting the heart using Klotho-hypomorphic mice rescued by dietary phosphate restriction.To avoid potential variations caused by strain and gender … meanders in the river thamesWebDr. Howard H. Kloth is a Cardiologist in New York, NY. Find Dr. Kloth's phone number, address, insurance information and more. meanders map packWebMar 22, 2024 · Heart disease is the leading cause of death worldwide. The major cause of heart failure is the death of the myocardium caused by myocardial infarction, detrimental … meanders in the river tees