Web3 feb 2024 · Cryo-electron microscopy of neddylated SCF-family ligases interacting with the RBR-type E3 ligase ARIH1 reveals the steps through which E3–E3 super-assemblies ubiquitylate a diverse set of ... WebARIH1 INFORMATION. Proteini. Full gene name according to HGNC. Ariadne RBR E3 ubiquitin protein ligase 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. ARIH1 (ARI, HARI, HHARI, UBCH7BP) Protein classi. Assigned HPA protein class (es) for the encoded protein (s).
The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and
WebList of PDB id codes. 1WD2, 2M9Y, 4KBL, 4KC9. Identifiers. Aliases. ARIH1, ARI, HARI, HHARI, UBCH7BP, ariadne RBR E3 ubiquitin protein ligase 1. External IDs. OMIM: … Web20 apr 2024 · Overexpression of ARIH1 suppresses tumor growth and promotes cytotoxic T cell activation in wild-type, but not in immunocompromised mice, highlighting the role of … jaw\\u0027s d8
Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super ...
WebMembers of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger … WebARIH1 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, ARIH1 Genome Browser, ARIH1 References. ARIH1 - Explore an overview of ARIH1, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. WebFinally, restoration of DNA damage-induced translation arrest in ARIH1-depleted cells by means of an eIF2 inhibitor was sufficient to reinstate resistance to genotoxic stress. These findings identify ARIH1 as a potent mediator of DNA damage-induced translation arrest that protects stem and cancer cells against genotoxic stress. kusen kayu meranti